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It does seem clear that chaffing, tight clothing and rubbing of fabric against skin is a factor. So the only obvious precaution would be to
wear loose clothing at all times. That is not really practical. Bras can feel tight. They can fit tighter at certain times of the month. Clothing binds at times and there is not anything most of us can do about that as we move about the world in our jobs and daily lives.
Even if we could avoid tight or chaffing clothing, we might still get skin tags as we age. So relax. They can be dealt with easily. See your doctor or simply apply Tag-FREE®.
How do skin tags affect daily life? 
They really don’t. There are times when there are several skin tags or dark-colored skin tags that appear on the face, neck or eyelids and they make the sufferer embarrassed, self-conscious or ill at ease with others. Remember, they can be surgically removed. Healing Leaf LLC’s Tag-FREE when applied faithfully twice a day will dispatch most skin tags quickly. Two weeks of twice-daily treatments easily remedies small skin tags. Do NOT use Tag-FREE® around the eye. The active ingredients will sting and burn the eyes.
Because skin tags are associated with aging, many people choose to eleminate these small growths. While it is extremely rare for them to cause harm, they can seriously affect the way we feel about ourselves. One woman who used Tag-FREE® had over two hundred skin tags on her neck and throat. Within a month of treating with Tag-FREE® her neck was smooth, healthy, and tag-free.
* These statements have not been evaluated by the FDA.